Abstract. In this work, composites of chitosan Bombyx mori (CS) with hydroxyapatite (HA) and their composites structure (CS/HA=50:50 wt. % and Ca/P=1.67%) studied by X-ray diffraction analysis and FITR spectroscopy. The acute toxicity of the composite was studied; after a single intragastric administration of the composites CS/HA=50:50 wt.% at doses from 1000 to 5000 mg/kg, the general condition of the mice remained stable and no visible changes were observed in their behavior. The LD50 of the chitosan hydroxyapatite preparation was >5000 mg/kg. Long-term administration of the drug into the body of animals with experimental osteoporosis led to an increase in the mass of the femur, bone compaction and an increase in the calcium content in the ashes of animal bones. The data obtained are of applied interest in the use of hydroxyapatite chitosan for the prevention and treatment of osteoporosis and the replacement of bone tissue in living organisms.
Key words. chitosan Bombyx mori, hydroxyapatite, in situ, non-toxicity, osteoporosis
DOI: http://uzpolymerjournal.com/articles/article.php?id=230210
Citation: Ergashev K.H., Vokhidova N.R., Rashidova S.Sh., CHITOSAN HYDROXYAPATITE BOMBYX MORI AND ITS EFFECT ON THE TREATMENT OF OSTEOPOROSIS. Uzbekistan Journal of Polymers, Vol. 2(2) 2023: pp.97-108. DOI: http://uzpolymerjournal.com/articles/article.php?id=230210
Announcement text goes here and the text goes here. We present an action from which the dynamics of homogeneous cosmologies can be derived. The action has no dependence on scale within the system and hence is more parsimonious in its description than the Einstein-Hilbert action.
Text text goes here and the text goes here. We present an action from which the dynamics of homogeneous cosmologies can be derived. The action has no dependence on scale within the system and hence is more parsimonious in its description than the Einstein-Hilbert action.