Open Access Received:   |   Accepted:   |   Published:

EMULSION MICROPARTICLES OF PROTEIN AND PECTIN FOR DRUG AND NUTRIENT DELIVERY PURPOSES

Usmanova S.R., Sherova Z.U., Kodirova G.A., Bobokalonov J.T., Muhidinov Z.K., Khalikov D.Kh.

Institute of Chemistry named after V.I. Nikitin of the National Academy of Sciences of Tajikistan

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Abstract. This article explores recent advancements in drug delivery systems (DDSs) using pectin polysaccharides (PP) derived from apples, sunflower, and citrus fruits, combined with whey and silk proteins to form stable emulsion particles in an oil-in-water (o/w) system. Optimal con-ditions for emulsion stability—including biopolymer ratios, pH, and ionic strength—were identified, enhancing pectin chain efficiency and enabling the formation of a robust interfacial layer. Polyphenolic compounds (PPhCs) encapsulated in these microcapsules, stabilized by sericin protein and apple pectin, demonstrated high antioxidant activity at minimal concentrations, confirming the preservation of their therapeutic properties. Remarkably, emulsions with high PPhC encapsulation maintained significant antioxidant activity even at 100-fold dilution. These findings contribute to developing biopolymer-based encapsulation technologies with potential applications in pharmaceuticals, food and cosmetics, agriculture, and molecular diagnostics.

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Key words. pectin, lactoglobulins, sericin, drug delivery system, emulsion.


DOI: http://uzpolymerjournal.com/articles/article.php?id=250106

*Corresponding author: Muhidinov Z.K., Institute of Chemistry named after V.I. Nikitin of the National Academy of Sciences of Tajikistan

Citation: Usmanova S.R., Sherova Z.U., Kodirova G.A., Bobokalonov J.T., Muhidinov Z.K., Khalikov D.Kh. , EMULSION MICROPARTICLES OF PROTEIN AND PECTIN FOR DRUG AND NUTRIENT DELIVERY PURPOSES. Uzbekistan Journal of Polymers, Vol. 4(1) 2025: pp.49-60. DOI: http://uzpolymerjournal.com/articles/article.php?id=250106

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