Article Info Vol. 3. Issue 1 (2024)

Open Access Received:   |   Accepted:   |   Published:

DETERMINATION OF ETHACIZINE IN BIOLOGICAL FLUIDS

Alikhodjaeva M., Boymuratov F.Т., Ataxanov A., Jalilov F.

Alfraganus University Department of Pharmacyand chemistry Uzbekistan.

Abstract. Currently, there has been a significant increase in cardiovascular pathology, and due to this, the frequency of use of antiarrhythmic drugs has noticeably increased.In the process of using drugs of this group, severe side effects are more likely to occur. In general, patients with structural heart disease have a higher risk of developing ventricular arrhythmias and proarrhythmias when using antiarrhythmic drugs, especially belonging to the class IC.The drug etacizine belongs to this class. The purpose of this study is to develop methods for the determination of the antiarrhythmic drug etacizine in biological fluids suitable for the practice of chemical and toxicological laboratories. The method is based on the detection, isolation and quantitative determination of etacizine from dosage forms and biological fluids using modern physicochemical methods of UV spectrophotometry, thermal desorption surface ionization spectroscopy. To purify extracts obtained from biological objects, the thin layer chromatography (TLC) method is used.


Key words. thin layer chromatography (TLC), UV spectrophotometry, Termodesorbtion Surface-Ionization (TDSI) spectroscopy, etacizine, blood, urine.


DOI: http://uzpolymerjournal.com/articles/article.php?id=240105


*Corresponding author: Alikhodjaeva M., Alfraganus University Department of Pharmacyand chemistry Uzbekistan.

Citation: Alikhodjaeva M., Boymuratov F.Т., Ataxanov A., Jalilov F., DETERMINATION OF ETHACIZINE IN BIOLOGICAL FLUIDS. Uzbekistan Journal of Polymers, Vol. 3(1) 2024: pp.57-64. DOI: http://uzpolymerjournal.com/articles/article.php?id=240105

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