Open Access Received:   |   Accepted:   |   Published:

WATER-SOLUBLE POLY(2-OXAZOLINES) AND THEIR SELECTED PHARMACEUTICAL APPLICATIONS

Khutoryanskiy V.V.

Reading School of Pharmacy, University of Reading, United Kingdom
Institute of Polymer Materials and Technologies, Almaty, Kazakhstan

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Abstract. Poly(2-oxazolines) were first synthesized in the 1960s by polymerisation of cyclic imino ethers. Now these polymers attract significant attention of researchers because of the possibilities to prepare various functionalised macromolecules of different architecture and their high biocompatibility. Methyl, ethyl, n-propyl and isopropyl derivatives of poly(2- oxazolines) are soluble in water. Some pharmaceutical applications of water-soluble poly(2- oxazolines) are considered in this mini-review. Attention is paid to the application of poly(2- oxazolines) for the preparation of solid dosage forms (tablets and films), mucus-penetrating nanoparticles, mucoadhesive derivatives, as well as solid drug dispersions and iodophors with antimicrobial properties.

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Key words. poly(2-oxazolines), water-soluble polymers, drug delivery, mucoadhesion, nanoparticles, solid dispersions, iodophors


DOI: http://uzpolymerjournal.com/articles/article.php?id=220107

*Corresponding author: Khutoryanskiy V.V., Reading School of Pharmacy, University of Reading, United Kingdom

Citation: Khutoryanskiy V.V., WATER-SOLUBLE POLY(2-OXAZOLINES) AND THEIR SELECTED PHARMACEUTICAL APPLICATIONS. Uzbekistan Journal of Polymers, Vol. 1(1) 2022: pp.73-82. DOI: http://uzpolymerjournal.com/articles/article.php?id=220107

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