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Abstract. In this paper, the results of medicinal compound’s polymeric forms, classification and principles of their development are discussed. The basic requirements for carrier polymers and polymers with their own biological activity are developed to create low-molecular drugs, their polymer forms and polymers with their own biological activity. Weak biological activity of a number of polyanions has been established as antitumor, immunomodulatory, interferon- inducing, and other activities. However, due to weak biological activity, they cannot be used in practical medicine. This work also considers the molecular construction of medicinal polymers that provide prolongation, selectivity, reduced side effects, preservation of therapeutic concentration in the body, reduced toxicity, and increased specific effects of the drug. The limitations for carrier polymers in molecular construction have been established, as well as in creation of polymer forms of drugs. A list of classes of drugs, for which the creation of their dosage forms is relevant, has been also defined. On the basis of the study results, it was concluded that drug polymers and their possible practical creation are in many cases unique and cannot be achieved with the use of low molecular weight drugs.
Key words. polymer, drug, biodegradations, cellulose, sodium-carboxymethylcellulose, nanostructured, biological activity
DOI: http://uzpolymerjournal.com/articles/article.php?id=220106
Citation: Sarymsakov A.A., Yunusov Kh.E., PERSPECTIVES ON CREATING POLYMERIC DRUGS. Uzbekistan Journal of Polymers, Vol. 1(1) 2022: pp.61-72. DOI: http://uzpolymerjournal.com/articles/article.php?id=220106
